Endocrine Abstracts

Goals: The purpose of this article is to describe an educational program of lifestyle intervention rather successful, taught for 25 groups of customers of a private hospital in Amazon, for a total of 2,215 individuals between 2008 and 2014, 1448 being female and male 767 and briefly assess its results in relation to some of the main risk factors.Methods: The PVS - Programa Vida Saudável, promotes evaluations and individual and group counselling, con...

The RET receptor tyrosine kinase is an established oncogenic driver in multiple cancers. Activating RET point mutations give rise to the cancer syndrome Multiple Endocrine Neoplasia type 2 (MEN2), characterized by medullary thyroid carcinoma and pheochromocytoma. Correlations of specific RET mutations with MEN2 disease phenotypes and severity have been well documented, however the molecular mechanisms that distinguish the functions, locations, and protein interactions of speci...

Background: Transphenoidal surgery is still the best initial therapy for Cushing’s disease (CD), with a high probability of cure and few risks or complications. However, pharmacotherapy has a role as primary or adjunctive therapy: when surgery is delayed, in case of postoperative persistence or recurrence of hypercortisolism, or while waiting for radiotherapy effectiveness. Ketoconazole, a steroidogenesis inhibitor, is nowadays the main drug used to CD control by reducing...